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doi: 10.1152/jn.1999.82.2.700

For commercial use please contact [email protected] Introduction Vitamin B12 (B12), or cobalamin, is a cobalt-containing compound, and exists in four forms, methylcobalamin (methyl-B12) and adenosylcobalamin (adenosyl-B12) that naturally occur in the body, and cyanocobalamin (cyano-B12) and hydroxocobalamin (hydroxo-B12) that are synthetic forms used in supplementation and food fortification

GPX4 reduces phospholipid hydroperoxides (PL-OOH) to their corresponding non-toxic phospholipid alcohol (PL-OH) using GSH as an electron donor, thereby preserving membrane integrity 95