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The neuropathology of genetic Parkinsons disease
For example, Nrf2, an important transcription factor in vivo , participates in the bodys antioxidant stress response by regulating the metabolism of GSH, iron, and lipids, as well as mitochondrial function, and activates the expression of several target genes involved in regulating ferroptosis (Shen et al., 2017)
This orchestrates ROS detoxification and cellular protection [452, 453]
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