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Witt et al
Furthermore, TSEL nanovesicles co-delivering BACE1 siRNA and a TREM2 plasmid effectively penetrated the BBB and accumulated at AD lesions in vivo in APP/PS1 mice (Jiang et al., 2024)
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The published preclinical work (Neelakantan et al., referenced via PMC5826726) reported clean safety at 20 mg/kg subcutaneous in mice over 11 days
