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Simon A, Monier F, Emonard H, et al

While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brains immune system, including microglia and astrocytes ( A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brains antioxidant defenses, one such defense being glutathione (GSH) (Tfilin et al., 2023)

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Live-cell confocal microscopy reveals increased number and size of mt-nucleoids in NaBt-treated cells, while mt-nucleoids are barely detectable in control cells (Fig