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To confirm this effect, a sufficiently large cohort should be included in the study and the analysis should include rare coding mutations

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Our results show that glutathione efflux from hepatocytes results in high local concentrations of both glutathione and cysteine in liver sinusoids, which transforms the nanoparticle surface chemistry, reduces its affinity to serum protein and significantly alters its blood retention, targeting and clearance

No anti-AOD9604 antibodies were detected in the subset of patients selected for antibody assay