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In contrast, in the PFD-treated group, there was only a significant reduction in vimentin (P = 0.007) and -SMA (P = 0.0004) compared to the induced (BLM) group, as shown in [Fig
ALA enhances and maintains cellular levels of GSH by acting as a transcriptional inducer of the genes that regulate its synthesis and by increasing substrate availability [31]
TFEB links autophagy to lysosomal biogenesis
Together, this tightly regulated buffering system allows cells to maintain zinc availability for signaling and enzymatic functions while avoiding the cytotoxic effects of free zinc
