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doi: 10.1530/EJE-10-0419 16 ButlerPWSmithSMLindermanJDBrychtaRJAlberobelloATDubazOMet al

Gly 182, 183, Leu 185, and Gly 186 are near the active site, whereas Gly 361 is far from the active site

This approach is being explored in fibrosis, neurodegenerative diseases, and cancer therapy.64,65 Modulation of Metabolic Pathways: Senescent cells exhibit altered metabolism, particularly increased reliance on glycolysis and mitochondrial dysfunction

ADP insensitivity impairs mitochondrial function in aging muscle including reports of decreased OCR and ATP production and increased reactive oxygen species (ROS) production at physiologically relevant concentrations of ADP [4,5,6,7]
