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however, a thorough investigation of metabolites, therapeutic efficacy, pharmacodynamics, and tissue distribution will be required for safety before clinical validation through human trials can be performed
doi: 10.1111/jnc.12127
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Organotypic Culture of Neonatal Mouse Cochleae Spiral Ganglion Neurons and Drug Treatments The C57BL/6 WT mice or gpx1 / mice were decapitated at postnatal day (P) 3, and only the middle turn segments of mouse cochleae were collected and cultured for all experiments to keep sampling consistence between groups
