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Higher doses were associated with greater weight loss within the initial 4 weeks of treatment [see Warnings and Precautions (5.5)]

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doi: 10.1002/iub.1324 34

The discovery of the vitamin D receptor in multiple immune cell lineages, such as monocytes, dendritic cells, and activated T cells credits vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases.[148] It is apparent that vitamin D has significant effects on the immune system and as such may contribute to the pathogenesis of autoimmune disease