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This lack of erinacine quantification led to the exclusion of a large majority of H

This feature is particularly useful in the treatment of IBD, as it allows drugs to be released primarily in the colon, where inflammation is most pronounced

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Several small-molecule chaperones, such as amiloride [151], AT2101 (isofagomine) [152] and histone deacetylase inhibitors [153], have been shown to increase GCase activity and reduce oxidative stress in PD fibroblasts carrying GBA1 mutations or enhance GCase activity in GBA macrophage models