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Sleep deprivation also inhibits mitophagy by suppressing the PINK1/Parkin pathway, allowing the accumulation of damaged mitochondria that further increase ROS and inflammation, accelerating neurodegeneration ( + -dependent deacetylases that govern metabolism, stress responses, and circadian gene expression, and altered NAD + /NADH ratios (Zhuang et al., 2024)
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Consequently, MPs/NPs have become widespread contaminants across diverse ecosystems and have infiltrated nearly every aspect of human life 5,6
