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Hundreds of differentially expressed genes (DEGs, both protein-coding and noncoding) between human and nonhuman primate samples were identified by RNA-seq of stem cell-derived astrocytes (iAstrocytes) 45

mTORC1 upregulation leads to accumulation of the oncometabolite fumarate in a mouse model of renal cell carcinoma

Gut 63(6):928937 Kennedy PJ, Cryan JF, Dinan TG, Clarke G (2017) Kynurenine pathway metabolism and the microbiota-gut-brain axis

Thus far, there has been little success in the treatment of FRDA