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5.3.8 Inhibition of angiogenesis Dihydroartemisinin inhibited tumor vascularization by decreasing the expression of HIF-1, VEGF, and endothelial cell-specific marker (CD31 and NG2) proteins, leading to a significant reduction in microvessel and mature vessel density in a time-dependent manner (Zhang et al., 2013)

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Hematoxylineosin (H&E) staining and immunohistochemistry The submandibular gland tissues embedded in paraffin were cut into 4-m-thick slices and then stained with hematoxylin and eosin (H&E) to evaluate inflammatory cell infiltration and histopathological damage