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It has a central role in maintaining cellular redox homeostasis, serves as a donor of methyl groups, and is a precursor for other sulfur-containing amino acids and compounds (Figure 3) (1, 6062)

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Hoffmann M., Kleine-Weber H., Schroeder S., Krger N., Herrler T., Erichsen S., et al

Matsumaru K

In addition, lower SIRT1 levels trigger the activation of apoptosis-related genes such as P66SHC and P53, which increases the susceptibility of hepatocytes to oxidative stress and programmed cell death
