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Furthermore, Nrf2 expression and activity decrease during aging [22, 23]
This mechanism was supported by the increase of molecules involved in GSH synthesis, such as intracellular cysteine (substrate of glutamate cysteine ligase, GCL) and -Glu-Cys (product of GCL and substrate of glutathione synthetase, GSS) shown in Figure 2
K.AdapaS
