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En un estudio farmacocintico, la administracin oral de amiodarona durante el tratamiento con orlistat, demostr una reduccin de 25-30% en la exposicin sistmica a la amiodarona y desetilamiodarona (Drug Saf, 2008;31(1):53-65)
Dieterle AM, Bhler P, Keppeler H, Alers S, Berleth N, Drieen S, et al
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Cell 173 , 17281741.e1713 (2018)
For instance, targeting the upstream kinases that phosphorylate HDAC6, thereby modulating its activity, or manipulating its protein-protein interactions, could offer new ways to fine-tune HDAC6's functions specifically in oxidative stress-related pathologies
