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The chosen method depends on the patients condition and the healthcare providers recommendation

At high concentrations, PDI acts as a chaperone to prevent aggregation by facilitating proper folding and production of target proteins, but can promote aggregation at lower concentrations [88, 89]

Alzheimer's disease via enhanced calcium signaling caused by the decrease of endoplasmic reticulum-mitochondrial distance

Gastroenterology 118:724734
