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The triangle of death in Alzheimers disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics

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The intrinsic pathway can be triggered either as a result of mPTP opening, or activation of the proapoptotic proteins of the B-cell lymphoma 2 (Bcl-2) family, Bax and Bak [192] after the removal of the block of antiapoptotic proteins Bcl-2 and Bcl-XL [193]

Lycopene represents a powerful, multi-targeted intervention in this healing process
