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A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes (p=0.270)

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If a patient cant tolerate allopurinol and meets the criteria (see above) for probenecid, that can be tried

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Proper storage is not just a logistics issue

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Therefore, vitamin B supplementation is very important to prevent the deficiency in both pre- and post-operative stage

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