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MEK inhibitors markedly reduced tumor growth in high-MAP3K8 PDX models, compared with low-MAP3K8 PDX models

Undeniably, Ca 2+ fluxes are crucial for almost all reported RCD pathways in erythrocytes, whereas in apoptosis, Ca 2+ elevation mediates primarily the mitochondrial outer membrane permeabilization (MOMP), triggering the intrinsic apoptosis [192]

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