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Once an antioxidant like Vitamin E or Vitamin C neutralizes a free radical, it becomes unstable itself

Response to Excessive and Reduced Stimulation of Receptors: Excessive Receptor Activation can result in desensitization or down regulation
doi: 10.5897/AJPP11.568 313 EdoGIMafeANRazooqiNFUmeloECGaazTSIsojeEFet al

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