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Polarized TH cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells

Abnormal double-stranded DNA can activate absent in melanoma 2 (AIM2), which further activates caspase-1, cleaves pro-IL-1 and pro-IL-18, and forms membrane pores on the cell membrane through the N-terminus of perforin D, releasing mature cytokines such as IL-1 and IL-18 (146)