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(2010), titled Effect of Acamprosate on Magnetic Resonance Spectroscopy Measures of Central Glutamate in Detoxified Alcohol-Dependent Individuals A Randomized Controlled Experimental Medicine Study, demonstrated that Acamprosate normalizes glutamate levels in the anterior cingulate cortex, a brain region associated with cravings and emotional regulation

Nature 2019 , 576 , 287292

Furthermore, IGF1R silencing mimicked the tumor-suppressive effects of miR-532 in CRC cells, further confirming its direct interaction with IGF1R, and miR-532 overexpression inhibited PI3K/AKT pathway activation both in vitro and in vivo (92)