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This effective scavenging of NO is consistent with the near diffusion-limited rate constant (2-8 10 7 M 1 sec 1 ) for substituting hydroxide for NO.47,48,49 The diffusion-controlled rate (i.e., the rate at which two species in solution can diffuse in order to react) is 10 9 to 10 11 M 1 sec 1

This is why the Food and Drug Administration recommends that ESAs only be used to achieve Hgb levels between 10g/dl and 12g/dl

It also important to remember that the sensation of fullness may cause a child to touch the spot where you administered the shot but this does not necessarily mean that this is a painful sensation