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Description
Experimental design, diets, and treatments The trial method used in this study was a randomized complete block design

Delivered under the skin or into a muscle, bypassing the gut
Phase 1: Retatrutide foundation (weeks 1-8) During this initial phase, the goal is to establish retatrutide tolerance before adding cagrilintide

TB-500 is dosed less frequently, typically once or twice per week during a loading phase and once every two weeks during maintenance, reflecting its longer half-life and systemic distribution pattern