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I think I linked to this paper below

What the Science Says About Combining NAD+ and 5-Amino-1MQ While no large-scale human trials have been published yet on the combined use of NAD+ therapy and 5-Amino-1MQ, interest in this area continues to grow, particularly in the fields of metabolic health and longevity medicine

Therefore, phase II/III clinical trials are enthusiastically recommended
Think of it like a carefully calibrated experiment