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EA can alleviate both macroscopic and microscopic colonic inflammation, upregulate the expression of claudin-1 and ZO-1 to repair the intestinal barrier, remold the overall structure of the gut microbiota, and inhibit pro-inflammatory factors IFN-, TNF-, and IL-6 through the MyD88-dependent TLR4 signaling pathway, preventing excessive immune response throughout the body (Liu et al., 2020)

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Some patients don't realize how depleted they felt until after starting supplementation