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doi: 10.1007/s00234-006-0167-z

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DheraniM.MurthyG

In a systematic review and meta-analysis, depression was associated with significantly increased oxidative stress as measured by biomarkers of oxidative DNA damage (8-OHdG) and lipid peroxidation (F-isoprostanes) compared to non-depressed controls ( 3.5 Neurotrophic deficits and impaired hippocampal neurogenesis The diminishment of neurotrophic signaling, especially that related to brain-derived neurotrophic factor (BDNF), stands as a defining characteristic of depression