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Description
In patients with HF, an increased production of reactive oxygen species leads to a decline in the bioavailability of NO and decreased NO-sGC-cGMP signalling [131]

Vidic, S. Zeljkovi, M
Cagrilintide: Long-Acting Amylin Analogue Research Guide Cagrilintide is a long-acting amylin analogue developed by Novo Nordisk, central to the REDEFINE clinical programme and co-formulated with semaglutide as CagriSema

While we have no evidence of an additive effect between RAD140 and FO, it is possible that prolonging the study from 14 days to 21 days may have given the RAD140 enough time to build up a more significant effect on muscle mass
