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Description
While treatment of hepatocytes with phenolic antioxidants induce binding of Nrf2/JunD/Maf to human GCLCs ARE4 to trans -activate the gene, it appears that TGF-1 treatment in type II alveolar cells induced binding of Fra-1/c-Jun dimer to the internal AP-1 sequence of the ARE4 site and suppressed GCLC expression (Jardine et al., 2002)
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Dutasteride should be initiated under physician supervision, with a discussion of the side-effect profile, reproductive considerations, and a monitoring plan
Matsui and Williams, 2010)
