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2024;11(43): Article e2404702

How quickly you respond depends on: How low your B12 levels are How long symptoms have been present Your overall health Whether there are underlying absorption problems Whether repeat treatment is needed It is important to have realistic expectations

Single newly published manuscripts with clear clinical relevance for the guideline development were included in the literature database until the end of guideline development process

In addition to the observed increase in mitochondrial fragmentation, the overexpression of FIS1 has also been demonstrated to result in mitochondrial dysfunction and an increase in autophagosome formation (Gomes and Scorrano, 2008)
