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[1] Causes of generalised hyperpigmentation include excessive sun exposure, drugs, Addisons disease and nutritional disorder such as Vitamin B12 deficiency

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something I want to make absolutely clear is this issue of over methylation or sensitivity to methyl donating remedies is very very uncommon, only seen a handful of times in 30 years practice, if you have an anxious brain and your mind latches onto this scary possibility remind yourself that the anxiety is messing with your mind and giving you a distorted and exaggerated perception of risk

Mechanisms associated with TDP-43 neurotoxicity in ALS/FTLD