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10.1016/j.synbio.2019.11.003

The skin serves several critical functions in the body, such as protection (against radiation, microorganisms, and mechanical, thermal, and chemical injuries), repair (responding to stress and altering its structure/composition during injuries), sensation (through mechanoreceptors, chemoreceptors, and nociceptors), thermoregulation (regulating body temperature of using insulation and sweating), synthesis of vitamin D, hormones and neurotransmitters, and excretion of water, uric acid, and ammonia [13]