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237 The therapeutic effects of the amino salicylic acid class drug sulfalazine, 238 the antibiotics azithromycin and buspirone, 239 the opioid agonist human opiorphin, 240 the PDE5 inhibitor sildenafil 241 and many other commonly used clinical drugs in UC are attributed to the inhibition of the NFB pathway, which inhibits the expression of inflammatory cytokines and the infiltration of inflammatory cells, alleviating intestinal epithelial damage

In the 80 participants, 12-week study, phenylethyl resorcinol was combined with three other actives (disodium glycerophosphate, L-leucine, and undecylenoyl phenylalanine) and only 57% of the participants showed at least a moderate response and 17% did not improve at all

PMID 19303062

Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease