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These doses are 7 times and 4 times the maximum recommended human dose calculated on a body surface area basis using total mg/m 2 /week in rodents and mg/m 2 /week for a 50 kg human

[Note: HDL particles are excellent acceptors of unesterified cholesterol as a result of their high concentration of phospholipids, which are important solubilizers of cholesterol.] Figure 18.23 Metabolism of high-density lipoprotein (HDL) particles

Existing challenges and limitations of developing an operational definition of CAIM While we anticipate that this operational definition of CAIM will provide much value to the future of CAIM research, it must be acknowledged that it is not without limitations, many of which are a result of a number of existing challenges that remain with respect to conducting research in this field

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