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Growth Horm IGF Res 2004;14:5965.ArticlePubMed 36

Damage to the intestinal barrier entails a number of adverse phenomena: dysbiosis, translocation of microorganisms deep into the intestinal tissue, immune response, development of chronic inflammation

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AOD-9604 is an intellectually interesting compound whose mechanism is well-characterized in preclinical models, whose safety profile is genuinely clean, and whose clinical program ultimately did not deliver