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32,35,215 However, at relatively high doses, methotrexate is also known to trigger a pro-oxidant state which further contributes to the structural and functional alteration of critical cell components, for example, lipids, proteins and DNA

Neuron 77: 528541, 2013
Ahmed MR, Basha SH, Gopinath D, Muthusamy R, Jayakumar R

Charge Density-Dependent Strength of Hydration and Biological Structure
