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One hypothesis now is that ME/CFS is caused, or partly caused, by impaired TRPM3 ion channels.[ref] Naltrexone acts on the mu-opioid receptors, which then can affect other cellular processes

All authors were involved in the drafting, critical review, revision, and final approval of the manuscript

Finally, the release of cytokines, tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8) by macrophages further mediates the local and/or systemic inflammatory responses

Therefore, controlled release of BAPPs can be achieved to a certain extent by changing intrinsic characteristics such as thickness dissolution and kinetics of the mineral coating [235]