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It is also relevant that in recent studies, we have shown that TMAO directly interacts with human platelets (both isolated and in whole blood), altering stimulus-dependent calcium signaling and promoting platelet hyperresponsiveness (4)

Some studies have shown that urea is increased in patients with COVID-19 [11]

Although an overall increase in mtDNA copy number did not affect immune cell infiltration in the lung, selective mtDNA deletion in lung adenocarcinoma (LUAD) cells significantly reduced tumor growth [316]

Although selenium deficiency, especially if severe, can impact thyroid health, it should be acknowledged that the role of selenium supplementation as a preventive or therapeutic strategy in thyroid diseases is highly controversial
