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Introduction When plants are exposed to various biotic and abiotic stresses, they exhibit characteristic increase in the production of reactive oxygen species (ROS) like singlet oxygen ( 1 O 2 ), superoxide (O 2 ), hydrogen peroxide (H 2 O 2 ) and hydroxyl radical (OH ) (Mittler et al., 2004)

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Fuhrmann found that the content of NCOA4 in macrophages decreased under hypoxic conditions, increasing intracellular ferritin content, and thereby enhancing macrophage resistance to ferroptosis [69]