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Description
Although the substance was discovered in 1905, its crucial role in metabolism was not elucidated until 1955, and its deficiency was not described until 1972 (Bhattacharyya 1995

A similar study was conducted with 466 Danish patients with cirrhosis

The strongest evidence comes from the DIVINe clinical trial, in which people with diabetic nephropathy taking 1,000 g/day of cyanocobalamin (plus folic acid and B6) experienced significantly faster decline in kidney function than the placebo group over 36 months (5.8 mL/min/1.73 m greater decline, p=0.02

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