glutathione histamine does increase Histamine Intolerance and How to Support Healthy Histamine Levels† — Seeking Health Pro-apoptotic effect of high concentrations
Description
By interfering with NF-kB nuclear translocation, KPV reduces the production of key pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6, all of which are elevated in active lupus

The benefit of this is that this higher dose can be injected in one shot and the benefits of B12 supplementation may be felt sooner
Vitamin B12 deficiency can damage the nervous system even in people who dont have anemia, so it is important to treat a deficiency as soon as possible

Look for licensed providers who specialize in medical weight loss or nutritional therapy