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Mechanistically, HNE inhibited the NLRP3 inflammasome activation independently of Nrf2 and NF-B signaling, and had no effect on the AIM2 inflammasome
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Matching tumors of relapsed versus newly diagnosed HGSOC patients also showed enhanced expression of AKR1B1, ITGAV, TGF1 and G6PD protein in relapsed tumors
