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In addition, we noted a significant decrease in liver weight and serum ALT/AST levels, with no effects on body weight, fat mass, food intake or induction of liver toxicity (Fig

Hartemann et al

H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells

These studies demonstrated that GCN2-deficient T cells are resistant to IDO-mediated proliferation arrest and TCR -chain downregulation, suggesting that GCN2 is crucial for IDO-mediated immune suppression (105, 109)
