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Description
Similar immune defects are observed in alcohol-related cirrhosis, including depletion and functional impairment of MAIT (mucosal-associated invariant T) cells and elevated soluble immune checkpoint molecules, such as sTIM-3 ( In our study, we utilized fumarylacetoacetate hydrolase (Fah)-/-, Rag2-/-, common cytokine receptor gamma chain knock-out (FRG-KO) humanized mice engrafted with HLA-A2-positive hepatocytes
2017 doi: 10.1111/ans.14295
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These investigations indicate that the peptide can interact with antimicrobial peptides and cellular defense mechanisms, potentially contributing to controlled immune responses during tissue remodeling
