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10.1002/ps.4859 16 CairnsN

Mice were first familiarized to the treadmill for three non-consecutive days for 5 min at a walking speed (8 m/min)

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However, the clinical translation of these approaches remains limited by the absence of standardized protocols for cell sources, dosages, and delivery routes, insufficient long-term safety data regarding genomic stability and tumorigenic risk, and the lack of large-scale randomized controlled trials comparing these novel approaches with established treatments (e.g., JAK inhibitors)