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As a dominant component of the gut microbiota, Faecalibacterium produces butyrate (21), which can not only suppress intestinal inflammatory responses by regulating immune cell differentiation (22), but also maintain the integrity of the intestinal barrier by enhancing intercellular tight junctions of intestinal epithelial cells (23)

As Winston Churchill said We need to go from failure to failure without losing our enthusiasm and ultimately we will succeed Recommendations for future research have been suggested by AAN and include the following: Figure 11