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The antimalarial medication quinine has long been used for cramp relief, but after increasing reports of side effects, most severely disseminated intravascular coagulopathy [193], the FDA limited and provided guidelines for the amount of quinine readily available in common formulations [194]

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The blot was blocked with Intercept-TBS (Li-Cor, Lincoln, USA) for 1 h at room temperature and incubated with mouse anti-FLAG antibody (M2, Sigma/Merck, Darmstadt, Germany, F3165) at a dilution of 1 g/ml

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