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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)

Moreover, NAC mitigates the inhibitory effect of PL on ZIKV replication 129

Within the mitochondria the first reaction of carnitine synthesis is catalyzed by the trimethyllysine hydroxylase, epison (also called trimethyllysine dioxygenase) enzyme encoded by the TMLHE gene

Taurine and L-methionine are other two sulfur-containing amino acids