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[DOI] [PubMed] [Google Scholar] [57].Paolisso G, Gambardella A, Ammendola S, DAmore A, Balbi V, Varricchio M, DOnofrio F
In vivo, emodin and tetrahydropalmatine synergistically reduces colon cancer (HT-29) tumor size, increasing F4/80 expression, decreasing IL-6 and TGF- levels, promoting tumor oxidation, and down-regulating p53 and STAT3 protein expression
However, in humans the data is contradictory
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